Von Willebrand's disease: an update.
نویسنده
چکیده
Von Willebrand disease (VWD) is the common autosomal bleeding disorder caused by a quantitative and/ or qualitative defect in the Von Willebrand Factor (VWF), a large multimeric multifunctional plasma glycoprotein which plays a critical role in hemostasis. It is essential for platelet adhesion to damaged endothelium as well as platelet interactions at high shear stress. VWF has a direct role in thrombin and fibrin generation by acting as a carrier molecule for the cofactor FVIII [1].
منابع مشابه
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ورودعنوان ژورنال:
- Texas medicine
دوره 75 10 شماره
صفحات -
تاریخ انتشار 1979